Résumé

Introduction: Our objective was to assess the detection and evolution of MDR-TB in Guin-ea from 2016 to 2019. Methodology: This was a 4-year historical cohort study (January 01, 2016 to December 31, 2019). We included multidrug-resistant tuberculosis patients, screened in Guinea from Janu-ary 2016 to December 2019. We conducted a united, multivariate analysis to highlight the main factors associated with success over the years of care. Results: We observed an increase in the number of MDR-TB cases from 137 in 2016 to 225 cases in 2019. The MDR-TB population was young and predominantly male (71%). The ma-jority of cases were reported to the Career Reference Tuberculosis Centre (34%) and the Tombolia Screening and Treatment Centre (33%). Retroviral serology was positive in 21% of patients. The evaluation of the treatment showed us that 35% of the patients were cured and 16% died. The comparative analysis of the different years allowed us to observe a sig-nificant difference between the results of the notification by center (p_value<0.001), the result of retroviral serology (p_value<0.001), the use of ARVs (p_value = 0.001), the initia-tion of the patient on cotrimoxazol (p_value = 0.003) and there was also a gradual decrease in the time to treatment (p_value<0.001). In the multivariate analysis in 2017 (p_value=0.034), management at the Tombolia CDT (p_value<0.001) and retroviral serology positivity were statistically associated with treatment success. Conclusion: MDR-TB increased gradually between 2016 and 2019, the factors associated with treatment success were retroviral serology, ARV use, Cotrimoxazol intake and treat-ment delay.

Mot-clés :

MDR-TB, therapeutic success, Guinea